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Abstract The promise of efficacious vaccines against SARS-CoV-2 is fulfilled and vaccination campaigns have started worldwide. However, the fight against the pandemic is far from over. Here, we propose an age-structured compartmental model to study the interplay of disease transmission, vaccines rollout, and behavioural dynamics. We investigate, via in-silico simulations, individual and societal behavioural changes, possibly induced by the start of the vaccination campaigns, and manifested as a relaxation in the adoption of non-pharmaceutical interventions. We explore different vaccine efficacy, vaccination rollout speeds, prioritization strategies, as well as multiple behavioural responses. We apply our model to six countries worldwide (Egypt, Peru, Serbia, Ukraine, Canada, and Italy) selected to sample diverse socio-demographic and socio-economic contexts. To isolate the...

IntroductionCoronaviruses are one of a group of RNA viruses that infect animals and humans, primarily the upper respiratory and gastrointestinal tract, which has recently caused a major illness in humans [1]. In 2002 there emerged the Severe Acute Respiratory Syndrome (SARS) in Southern China, causing about 8,098 infections, and 774 deaths in almost 17 countries [2]. Also, there emerged Middle East Respiratory Syndrome (MERS) in 2012, with 536 Laboratory confirmed cases and 145 deaths [3]. In late December 2019, a new coronavirus emerged, causing pneumonia in people, and have been named COVID-19 (caused by novel SARS-CoV-2 coronavirus) [1]. The outbreak of the COVID-19 has raised a lot of health and economic concerns for health authorities and governments in the world.The preventive measures that were used for other coronaviruses (SARS and MERS) are being used to reduce the...